Expertise & research as leitmotifs

Pharmaceutical Synthesis

Pharmaceutical Synthesis

“Process" R & D is supported by a team of over 60 scientists, half of whom hold doctorates or engineering doctorates in chemistry. It is divided into two separate parts:

  • Pharmaceutical synthesis in a GMP regulatory environment
  • Pharmaceutical synthesis in an ISO-900 regulatory environment

Advanced technologies

  • A dedicated team of scientists(PhD, engineers and technicians), share their skills to develop advanced technologies. They generate know how in the field of glass and material coating, specialty polymers and product dedicated to cosmetics and personal care.

Performance products

  • A team of scientists dedicated to the elaboration ad improvement of admixture for Industrial lubrication and long term protection against corrosion, used in the field of metal treatment.

focus

Key operations

  • Process optimization
  • Study of 'Safety' parameters
  • Process scale-up

Highly specific areas of expertise

  • Cryogenic reactions (Main Plant + Pilot Plant)
  • Photo-oxidation (Pilot Plant)
  • Nano-filtration (Pilot Plant)
  • Continuous liquid-liquid extraction (Pilot Plant)
  • Continuous reaction (Laboratory)
  • Crystallographic studies:
    • Polymorph research and identification
    • Particle size distribution
  • Hydrogenation capacities:
  • From 500 to 6,000 liters and from 4 bars to 35 bars
    • Industrial distillation expertise

    Industrial technologies, following the first R&D implementations

    • C-1 Technology: use of cyanide and formaldehyde
    • C-2 Technology: use of ethylene oxide and Horner-Wittig-Emmons reactions
    • C-3 Technology: use of acrolein derivatives
    • C-C bond formation using transition metals
    • C-C Technology on aromatic cores: Friedel & Craft alkylation & acylation
    • C-C Technology, on double bonds with control of chirality:
      • Diels-Alder reaction & Sharpless oxidation-type reactions

    Introduction of chirality using:

    • the Diels-Alder reaction
    • the Sharpless reaction
    • diastereoisomeric salts
    • dynamic enzymatic resolution (DKR)
    • enzymatic reduction (ADH)
    • asymmetric induction using chiral additives
    • resolutions based on preferential crystallization

    A specific body of knowledge in the following fields

    • phosphonates and bis-phosphonates (implementation of the Arbusov reaction)
    • phosphorus oxychloride (P(O)Cl3), chlorinating agent (Bischler-Napieralski)
    • thiophene (synthesis and multiple functionalizations)
    • cyclopentadiene (generation, industrial use)
    • handling of very strong bases (BuLi, LDA, LiHMDS, etc.)
    • handling of hydrides (LiAlH4, NaBH4, DIBAH, L-Selectride, etc.)

    Specific handling of the chemical classes indicated below:

    • halogenides (chlorine, bromine, iodine and fluoridation agents and chalcogenides (O,S, etc.)
    • alkaline metals and their salts (Li, Na, K, Cs, etc.)
    • vary strong basic reagents
    • alkaline-earth metals (Mg, Ca)

    Specific Skills dedicated to coatings and materials:

    • Chemical vapor deposition of organometallics
    • Polymer analysis: G.P.C., Rheology
    • Thermal conductivity
    • Analysis of metal impurities by I.C.P. – M.S.

    Contacts: