Services
- Evaluation of synthetic routes.
- Laboratory Development of industrial process for key intermediates or advanced intermediates manufacturing.
- Scaling-up processes to commercial scale.
- Development of analytical procedures to support the process and to analyse the final product.
- In-house impurities and reference standards.
- Assistance for regulatory documentation.
People
PCAS R&D team consists of dedicated and highly qualified experts in their respective fields:
- PhD's and MSc's specialized in the development and scale-up of organic synthetic routes.
- PhD's and MSc's specialized in the development of analytical methods.
- Trained technicians complete the project team.
Specific project teams are formed to fulfil the needs of each project and to take into account all aspects of the research work. We keep our customers updated on the progress made and we emphasize the importance of mutual communication in our daily work.
Organic Synthesis Comprehensive Platform
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Analytics: Synthetic chemistry at PCAS is backed by state-of-the-art comprehensive analytical technologies:
- 200 MHz NMR
- HPLC equipment
- GC equipment
- GC-MS equipment
- Ion exchange chromatography
- Gel permeation chromatography
- Graphite furnace atomic absorption
- ICP-MS
- UV equipment
- Infrared spectroscopy
- DSC equipment
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Special Equipment and technologies:
- Autoclave : 0,5 l and 3,0 l
- Photo-sensitive compounds handling under inactinic light
- Biotage preparative chromatography
- Acrolein Safe handling
- Safe handling of hydride and Lithium reagents
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Performance Product testing
PCAS has decades of experience and is fully equipped to evaluate a wide range of performance products: within "performance testing", as an example, PCAS can measure dissolution rate of polymer films using a dissolution rate monitor.
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Additives & Technical fluids
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Salt spray test
- TIMKEN Test Machine
- 4- Ball test Machine
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Graphics - Arts- Polymers
- Inactinic laboratory
- Photosensitive plate coating equipment
- UV-Insolator
- Determination of dissolution rate of polymer films
- Solid support resins
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Glass surfaces treatment capabilities
- Pyrolytic deposit equipment
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Process safety studies
Safety studies are fully integrated throughout the process development work. Each Project team is backed by a dedicated expert (PhD) in safety to address all relevant issues, e.g. thermal stability, reaction heat, accumulation problems, etc.
Equipment:
- automated reaction calorimeter ('Algochem')
- DSC Equipment
Analytical Development
Analytical development support for synthetic chemists at various levels: Lab K-Lab, Pilot Plants, Workshops.
Analytical chemistry is a key supporting service from process development up to Quality Control testing. PCAS develops molecules to meet within specifications. A broad range of analytical methods are implemented, especially chromatographic ones, to ensure compliance to the specifications, identify impurities and much more.
Highly skilled and trained analytical chemists perform qualitative and quantitative analysis. They master the science of sampling, defining, isolating, concentrating, and preserving samples. They set error limits, validate and verify results through calibration and standardization, perform separations based on differential chemical properties, create new ways to make measurements, interpret data and communicate results.
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A wide range of chromatographic techniques
- Gravimetry
- Spectroscopy (atomic absorption, ultraviolet-visible, infrared, nuclear magnetic resonance...)
- Mass Spectrometry
- Thermal Analysis (calorimetry, thermogravimetric analysis)
- Separation (GC, HPLC, Head Space-GC, Gel permeation chromatography)
- Hybrid Techniques (GC-MS, LC-MS)...
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Scale-Up
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Kilo-laboratory
Kilo-Lab reactor is currently used for the early scale-up and the first significant quantities.
Kilo-lab equipment: 15 L, 30 L, 50 L and 60L reactors.
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Pilot workshops
Integrated into R&D, the pilot is a key link in the transfer to production and fully operating under ISO 9001 environment.
Pilot equipment consists of :
- double jacketed Inox reactors and or glass-lined with temperature range - 15°C- +150°C ( from 100 L up to 800 L)
- 100 L distillation column ( 2 mm Hg vacuum)
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